Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3208 | 3208-30515 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82ST, L90M | L10V, T12I, G16GA, M36MI, N37D, R41K, I62IV, L63P, A71V, I72V, I93L |
| >3208-30515| codons 1-99 PQITLWQRPVVIIKIAGQLKEALLDTGADDTVLEEIDLPGKWKPKLIVGIGGFVKVRQYD QVPIEICGHKVVGTVLVGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, L210W, T215Y | K103S, G190A | A98G | E6D, T7I, K43E, E53D, I94IL, K122P, I135T, I142V, S162HY, I167IV, V189I, I195IL, L228H, I244V, A272P, K275R, Q278H, T286TP, A288S, I293IV, K311R, T338TA, K350R, R356K, G359S, T369V, S379C, K390R |
| >3208-30515| codons 1-400 PISPIDIVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPDNPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGLPHPGGLKKSKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKVLEPFRKQNPDIVI YQYVDDLYIASDLELGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCKLLRGPKSLTEVVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWAYQIYQEPFKNLRTGKYAKMRSA HTNDVKQLVEAVQKIATECIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |