<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3208 3208-30515 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82ST, L90M   L10V, T12I, G16GA, M36MI, N37D, R41K, I62IV, L63P, A71V, I72V, I93L  
>3208-30515| codons 1-99
PQITLWQRPVVIIKIAGQLKEALLDTGADDTVLEEIDLPGKWKPKLIVGIGGFVKVRQYD
QVPIEICGHKVVGTVLVGPTPTNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, M184V, L210W, T215Y   K103S, G190A A98G E6D, T7I, K43E, E53D, I94IL, K122P, I135T, I142V, S162HY, I167IV, V189I, I195IL, L228H, I244V, A272P, K275R, Q278H, T286TP, A288S, I293IV, K311R, T338TA, K350R, R356K, G359S, T369V, S379C, K390R  
>3208-30515| codons 1-400
PISPIDIVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPDNPYNTPV
FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGLPHPGGLKKSKSVTVLDVGDAYFSVPL
DPDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKVLEPFRKQNPDIVI
YQYVDDLYIASDLELGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCKLLRGPKSLTEVVPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWAYQIYQEPFKNLRTGKYAKMRSA
HTNDVKQLVEAVQKIATECIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006