Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3207 | 3207-30515 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | K43T, F53L, G73S | L10I, I15V, G16A, E35ED, M36I, K55R, Q61E, I62V, L63P, A71V |
| >3207-30515| codons 1-99 PQITLWQRPIVTIKVAGQLKEALLDTGADDTILEDINLPGRWTPKIIGGIGGLVRVRQYD EVPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, M184V, T215F | K219Q | Y181C, G190A | V108VI | T69N, K122E, Q207A, K223Q, L228H, A272P, K277R, I293IV, E297K, I329L, G333E, A360AT, K366R, T369V, Q394L, E399D |
| >3207-30515| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRAHLLRWGFFTPDQKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLVEAVQKIATESIVIWGKTPKFKLPILKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |