Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3206 | 3206-30512 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A, L90M | L33LF | L10I, G16A, K20R, M36I, N37D, I62V, L63P, A71V, I72V, I93L |
| >3206-30512| codons 1-99 PQITLWQRPIVTIKIAGQLREALLDTGADDTVFEEIDLPGRWKPKLIVGIGGFSKVRQYD QVPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, V75T, M184V, T215F | K219Q | Y181C, G190S | A98G | E6D, K43NS, V118I, K122E, V179T, F214L, D218E, L228H, V245M, T286A, E297K, K311KR, I329L, K350R, R356K, M357T, A376T, T386A, K390R |
| >3206-30512| codons 1-398 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELESEGKISKIGPENPYNTPV FAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDITI CQYVDDLYVSSDLEIGQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILREPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLRTGKYAKTRGA HTNDVKQLTEAVQKITTESIVIWGKAPKFRLPIQKETW |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |