Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3204 | 3204-30604 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, V75M, M184V, L210W, T215Y | K103N, G190A | V35I, T39TA, E40F, K43E, K102N, V118I, K122E, D123E, I135T, S162C, Q174H, G196E, T200A, I202V, R211K, D250DE, Q278E, I293IV, E297R, D324E, I329L, R356K, M357L, A360T, A376S, T377TI, S379C, V381VI, K390R, E399D | N54I |
| >3204-30604| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAFLEEEGKISKIGPEIPYNTPV FAIKKKNSDKWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKNNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKHNPDIVI YQYVDDLYVASDLEIEQHRAKVEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKELCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKLRGT HTNDVKQLTEAVQKISIECIIIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | L33F | L10I, I13V, G16E, K20M, M36I, P39S, Q61QH, I62V, L63Q, I64V, T74AS |
| >3204-30604| codons 1-99 PQITLWQRPIVTVKIEGQLMEALLDTGADDTVFEEINLSGRWKPKLIGGIGGFVKVRQYD HVQVEICGHKAIGSVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |