<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3204 3204-30604 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V L33F L10I, I13V, G16E, K20M, M36I, P39S, Q61QH, I62V, L63Q, I64V, T74AS  
>3204-30604| codons 1-99
PQITLWQRPIVTVKIEGQLMEALLDTGADDTVFEEINLSGRWKPKLIGGIGGFVKVRQYD
HVQVEICGHKAIGSVLVGPTPANVIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, M184V, L210W, T215Y V75M K103N, G190A   V35I, T39TA, E40F, K43E, K102N, V118I, K122E, D123E, I135T, S162C, Q174H, G196E, T200A, I202V, R211K, D250DE, Q278E, I293IV, E297R, D324E, I329L, R356K, M357L, A360T, A376S, T377TI, S379C, V381VI, K390R, E399D N54I
>3204-30604| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAFLEEEGKISKIGPEIPYNTPV
FAIKKKNSDKWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKNNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKHNPDIVI
YQYVDDLYVASDLEIEQHRAKVEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKELCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKLRGT
HTNDVKQLTEAVQKISIECIIIWGKTPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006