Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3203 | 3203-30528 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, T215F | K219Q | L100I, Y188L | V35M, T39A, K43E, T69N, K122E, I135L, I142L, Q174N, V179I, Q207E, R211K, L228H, K238R, A272P, K277R, E297K, I329V, Q334I, A371V, K390R |
| >3203-30528| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAEMEEEGKISKIGPENPYNTPV FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGLRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKNNPDIII YQYMDDLLVGSDLEIGQHRTKIEELREHLLKWGFFTPDQKHQKEPPFHWMGYELHPDRWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGIGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82F, L90M | V11I, L33F, G73T, L89V | L10I, T12P, K14R, N37D, R57K, I62V, L63P, A71V, V77I, I85V, I93L |
| >3203-30528| codons 1-99 PQITLWQRPIIPIRIGGQLKEALLDTGADDTVFEEMDLPGRWKPKIVGGIGGFVKVKQYD QVPIEICGHKVITTVLIGPTPFNIVGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |