<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3203 3203-30528 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82F, L90M V11I, L33F, G73T, L89V L10I, T12P, K14R, N37D, R57K, I62V, L63P, A71V, V77I, I85V, I93L  
>3203-30528| codons 1-99
PQITLWQRPIIPIRIGGQLKEALLDTGADDTVFEEMDLPGRWKPKIVGGIGGFVKVKQYD
QVPIEICGHKVITTVLIGPTPFNIVGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, L74I, T215F K219Q L100I, Y188L   V35M, T39A, K43E, T69N, K122E, I135L, I142L, Q174N, V179I, Q207E, R211K, L228H, K238R, A272P, K277R, E297K, I329V, Q334I, A371V, K390R  
>3203-30528| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAEMEEEGKISKIGPENPYNTPV
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSLNNETPGLRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKNNPDIII
YQYMDDLLVGSDLEIGQHRTKIEELREHLLKWGFFTPDQKHQKEPPFHWMGYELHPDRWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGIGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006