Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3201 | 3201-30514 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219E | Y181C, G190GS | K43E, E44A, K101Q, V118I, K122E, I142IV, S162SN, G196GE, E203EK, Q207E, K275Q, V276T, T286N, I293V, P294T, E297K, R356K, G359S, K366R, E399D | Y339YH |
| >3201-30514| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI CQYVDDLYVSSDLEIEQHRTKIKELREHLWRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIQTKQLCKLLRGNKALTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTHQIYQEPFKNLKTGKYAKMRSA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, L90M | L33F, G73S | L10I, I13V, I62V, L63P, A71V, I72E, V77I |
| >3201-30514| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFLKVRQYD QVPIEICGHKVESTVLIGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |