<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3200 3200-30515 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, L76V, I84V, L90M L33F, G73T L10I, I13V, G16A, E34Q, N37NHRS, R41RK, K55R, L63P, A71V, I93L L89S
>3200-30515| codons 1-99
PQITLWQRPIVTVKIAGQLKEALLDTGADDTVFQEMSLPGKWKPKIIGGIGGFLRVRQYD
QIPIEICGHKVITTVVVGPTPVNVIGRNSMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y V75M K103S   E6K, M16V, K20R, V35I, T39A, E40F, K43E, V118I, K122E, I135T, D177N, T200A, Q207D, H208Y, R211K, A272P, T286A, A288S, Q334E, A355G, M357T, A371V, A376T, A400S E203AT
>3200-30515| codons 1-400
PISPIKTVPVKLKPGVDGPRVKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI
YQYVDDLYVGSDLEIGQHRAKITELRDYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYGRTRGA
HTNDVKQLTEVVQKITTESIVIWGKTPKFKLPIQKETWES

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006