Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3199 | 3199-30507 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54L, I84V, L90M | G73T | L10I, V11L, I15V, Q18H, L19P, K20I, A22V, E34Q, M36I, K55R, L63P, I64V, A71V, I72L, I85V |
| >3199-30507| codons 1-99 PQITLWQRPILTIKVGGHPIEVLLDTGADDTVLQEINLPGRWKPKIVGGIGGFLRVRQYD QIPVEICGHKVLTTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219N | Y181C | A98G | V35M, E44D, V60I, V118I, K122E, D123S, I135T, S162A, K166Q, E169D, V179I, T200K, H208Y, R211K, D218E, V245E, A272P, K277R, A288S, I293V, D324E, A360T, T386I, E399D |
| >3199-30507| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTQILDPFRKQNPDIII CQYVDDLYVGSDLEIGQHRKKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |