Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3197 | 3197-30507 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82C, I84V, L90M | L10F, L33F, G73T | L19I, E34Q, R41K, L63P, A71V, I93L |
| >3197-30507| codons 1-99 PQITLWQRPFVTIKIGGQIKEALLDTGADDTVFQEMNLPGKWKPKIIGGIGGFVKVRQYD QIPIEICGHKVITTVLVGPTPCNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69DE, K70KR, Q151M, M184V | A62V, V75I, F116Y, T215V, K219Q | Y181I, G190A | V108VI, V179E | K20R, T27S, E28A, K32KQ, V60I, R83K, K103KR, V118I, K122E, I135V, K173E, I202V, F214L, E224D, L228H, V245M, D250S, A272P, K277R, Q278E, L283I, A288T, I293V, E297Q, G335D, R356K, G359S, T386I, K390R | E138V, L209LM, L325L* |
| >3197-30507| codons 2-399 ISPIETVPVKLKPGMDGPRVKQWPLSAEKIQALVEICTEMEKEGKISKIGPENPYNTPIF VIKKKNSERWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTILDVGDAYYSIPLD EDFRKYTAFTIPSVNNVTPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFREQNPDIEII QYVDDLYVASDLEIGQHRTKVEELRQHMLRWGLVTPDQKHQKDPPFHWMGYELHPDKWTV QPIMLPEKSSWTVNDIQKLVGKLNWASQIYPGIKVRELCKLIRGTKTLTEVVPLTQEAEL ELAENREILKEPVHGVYYDPSKD*IAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKMRSAH TNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |