<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3196 3196-30506 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, M184I, L210W, T215Y K219R, N348I K101E, Y188L   E6D, V35I, K43E, E44A, A98AS, V106I, V118I, K122E, I135T, K166R, D177G, V179VI, G196GR, H208Y, R211K, K223EQ, E224D, L228LH, A272AP, K277R, D324E, I341F, M357T, G359S, K366R, T386I  
>3196-30506| codons 1-400
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPSGLEKKKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPGIII
YQYIDDLLVGSDLEIRQHRTKIEELRQYLWKWGFYTPDRKHQQDPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQFYQEPFKILKTGKYARTRSA
HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, I84V, L90M V11I, L89V L10I, I13A, K14R, K20R, A22V, E35D, M36I, N37D, I62V, L63P, I66IV, A71V, Q92K, I93L  
>3196-30506| codons 1-99
PQITLWQRPIITARIGGQLREVLLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVRQYD
QVPIEVCGHKVIGTVLVGPTPVNVIGRNVMTKLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006