Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3196 | 3196-30506 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | V11I, L89V | L10I, I13A, K14R, K20R, A22V, E35D, M36I, N37D, I62V, L63P, I66IV, A71V, Q92K, I93L |
| >3196-30506| codons 1-99 PQITLWQRPIITARIGGQLREVLLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVRQYD QVPIEVCGHKVIGTVLVGPTPVNVIGRNVMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184I, L210W, T215Y | K219R, N348I | K101E, Y188L | E6D, V35I, K43E, E44A, A98AS, V106I, V118I, K122E, I135T, K166R, D177G, V179VI, G196GR, H208Y, R211K, K223EQ, E224D, L228LH, A272AP, K277R, D324E, I341F, M357T, G359S, K366R, T386I |
| >3196-30506| codons 1-400 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPSGLEKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPGIII YQYIDDLLVGSDLEIRQHRTKIEELRQYLWKWGFYTPDRKHQQDPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQFYQEPFKILKTGKYARTRSA HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |