<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3193 3193-30512 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y       T39A, E44D, K101Q, V118I, K122E, D123N, I135T, T200A, H208Y, R211K, V245VE, A272P, L283I, I293V, S322AT, P345Q, R356K, G359S, A371V, T386IV, K390R  
>3193-30512| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPVF
AIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPLD
ENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTV
QPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAEL
ELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYAKMRSAH
TNDVKQLTEVVQKIATESIVIWGKVPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, K43T L10V, I13V, K14R, K20Q, E35D, M36L, N37E, K55R, R57K, D60E, I62V, L63P, A71T, T91S, I93L, C95F  
>3193-30512| codons 1-99
PQITLWQRPVVTVRIGGQLQEALLDTGADDTVFEDLELPGRWTPKIIGGIGGFVRVKQYE
QVPIEICGHKTIGTVLVGPTPANIIGRNLMSQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006