Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3193 | 3193-30512 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, K43T | L10V, I13V, K14R, K20Q, E35D, M36L, N37E, K55R, R57K, D60E, I62V, L63P, A71T, T91S, I93L, C95F |
| >3193-30512| codons 1-99 PQITLWQRPVVTVRIGGQLQEALLDTGADDTVFEDLELPGRWTPKIIGGIGGFVRVKQYE QVPIEICGHKTIGTVLVGPTPANIIGRNLMSQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | T39A, E44D, K101Q, V118I, K122E, D123N, I135T, T200A, H208Y, R211K, V245VE, A272P, L283I, I293V, S322AT, P345Q, R356K, G359S, A371V, T386IV, K390R |
| >3193-30512| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPVF AIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPLD ENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY QYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTV QPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAEL ELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYAKMRSAH TNDVKQLTEVVQKIATESIVIWGKVPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |