Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3190 | 3190-30604 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33I, K43T, F53L, L89V | L10I, I13V, L19I, K20R, A22V, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72T, Q92K |
| >3190-30604| codons 1-99 PQITLWQRPIVTVKIGGQIREVLLDTGADDTVIEDINLPGRWTPKLIGGIGGLVRVKQYE QVPIEICGHKVTGTVLVGPTPANIIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74V, M184V, L210W, T215Y | K219E | Y181C | V108I | K20R, V35M, T39A, K43E, E44A, K49R, K101Q, V118I, K122E, I135M, Q174K, R211T, L228H, Q242H, L283I, A288S, L325LI, I329V, R356K, M357K, G359S, A371V, K390R |
| >3190-30604| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEAGKISRIGPENPYNTPV FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWTWGFYTPDEKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKSLTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDIIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |