Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3189 | 3189-40604 | France | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 56 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L76V, V82AT, L90M | K43T | L10V, I15V, N37D, K55R, R57K, D60E, I62V, L63P, H69R, A71V, L89M, I93L |
| >3189-40604| codons 1-99 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEEMDLPGRWTPKIVGGIGGFMRVKQYE QVPIEICGRKVIGTVVVGPTPTNIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74LI, T215F | K219Q | K101P, K103N | E6K, A98AS, V118I, K122E, I135T, Q174H, Q197E, T200A, R211T, F214L, D218E, V245A, E248D, A272P, I293V, E297K, V317A, G333E, Q334Y, M357T, T386I |
| >3189-40604| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPSGLPKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIGEHRAKIEELRQHLLTWGLFTPEQKHQKEPPFLWMGYELHPDKWT VQPIALPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |