Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3188 | 3188-30505 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L33F | L10I, V11L, I13V, E34Q, N37D, L63P, I66IV, A71IL, V77I, I93L |
| >3188-30505| codons 1-99 PQITLWQRPILTVKIGGQLKEALLDTGADDTIFQEMDLPGRWKPKIVGGIGGFMKVRQYD QIPIEVCGHKLIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, L210W, T215Y | N348I | K103N | K43Q, A98S, K102R, V118I, K122E, K166R, D177N, G196E, D218DN, A272P, Q334N, P345T, R356K, M357S, T377Q |
| >3188-30505| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHPSGLKRNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPNKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQETFKILKTGKYAKSRGA HTNDVKQLTEAVQKIAQESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |