Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3187 | 3187-30428 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y181I | A98G | V118I, K122E, I135T, V179I, E203K, Q207E, R211K, F214L, K223Q, L228H, A272P, I293V, V317VA, G333E, Q334H, G335GC, F346HY, G359S, T386I |
| >3187-30428| codons 2-400 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVF AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPLD EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIIII QYVDDLYVGSDLEIGQHRTKIKELREHLWKWGLYTPDKKHQQEPPFHWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAEL ELAENREILKEPVHGAYYDPSKDLIAEIQKQEHCQWTYQIYQEPYKNLKTGKYARMRSAH TNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A, L90M | K43KT | L10V, I15V, K20R, M36I, N37D, I62V, L63P, A71I, I72V, Q92K, I93L, C95V |
| >3187-30428| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEEIDLPGRWTPKLIGGIGGFAKVRQYD QVPIEICGHKIVGTVLVGPTPANIIGRNLMTKLGVTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |