<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3187 3187-30428 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   Y181I A98G V118I, K122E, I135T, V179I, E203K, Q207E, R211K, F214L, K223Q, L228H, A272P, I293V, V317VA, G333E, Q334H, G335GC, F346HY, G359S, T386I  
>3187-30428| codons 2-400
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPLD
EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIIII
QYVDDLYVGSDLEIGQHRTKIKELREHLWKWGLYTPDKKHQQEPPFHWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAEL
ELAENREILKEPVHGAYYDPSKDLIAEIQKQEHCQWTYQIYQEPYKNLKTGKYARMRSAH
TNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54A, V82A, L90M K43KT L10V, I15V, K20R, M36I, N37D, I62V, L63P, A71I, I72V, Q92K, I93L, C95V  
>3187-30428| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEEIDLPGRWTPKLIGGIGGFAKVRQYD
QVPIEICGHKIVGTVLVGPTPANIIGRNLMTKLGVTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006