<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3186 3186-30506 France 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, T215Y K219N K103N, G190A A98G V35T, T39A, E44D, V60I, V118I, K122E, D123S, K173R, Q174K, D177E, V179T, T200A, Q207E, L210S, R211K, L228H, Q242H, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, L301M, I329V, Q334P, G335D, F346Y, M357R, R358G, G359S, A371V, A376S, I382V, Q394K, E399D R206M, T216M
>3186-30506| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEITI
YQYVDDLYVASDLEIGQHRAKIEELMEHLSKWGFYMPDNKHQKEPPFHWMGYELHPDKWT
VHPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE
MELAENREILKEPVHGVYYDPSKDLIAEVQKQGPDQWTYQIYQEPYKNLKTGKYARRGSA
HTNDVKQLTEVVQKISTESIVVWGKTPKFKLPIKKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V V11I, L24I, L89IV L10I, I13A, K14R, K20I, A22V, E35D, M36I, R41K, I62V, L63P, C67Y, H69K, A71V, T74S, Q92K  
>3186-30506| codons 1-99
PQITLWQRPIITARIGGQLIEVLIDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVRQYD
QVPIEIYGKKVIGSVLVGPTPANVIGRNVLTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006