Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3186 | 3186-30506 | France | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | V11I, L24I, L89IV | L10I, I13A, K14R, K20I, A22V, E35D, M36I, R41K, I62V, L63P, C67Y, H69K, A71V, T74S, Q92K |
| >3186-30506| codons 1-99 PQITLWQRPIITARIGGQLIEVLIDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVRQYD QVPIEIYGKKVIGSVLVGPTPANVIGRNVLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | K219N | K103N, G190A | A98G | V35T, T39A, E44D, V60I, V118I, K122E, D123S, K173R, Q174K, D177E, V179T, T200A, Q207E, L210S, R211K, L228H, Q242H, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, L301M, I329V, Q334P, G335D, F346Y, M357R, R358G, G359S, A371V, A376S, I382V, Q394K, E399D | R206M, T216M |
| >3186-30506| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEITI YQYVDDLYVASDLEIGQHRAKIEELMEHLSKWGFYMPDNKHQKEPPFHWMGYELHPDKWT VHPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE MELAENREILKEPVHGVYYDPSKDLIAEVQKQGPDQWTYQIYQEPYKNLKTGKYARRGSA HTNDVKQLTEVVQKISTESIVVWGKTPKFKLPIKKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |