<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3185 3185-30429 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, V75T, M184V, T215F K219Q K101P, G190A   V35I, K43Q, E44D, K64R, V111I, V118I, D123E, S162D, D177E, V179I, G196E, E203K, Q207D, H208Y, R211K, D218E, D237DE, A272S, T286A, A288S, I293V, P294T, E297KR, I326IV, Q334L, G335GS, R356K, G359S, A360AT, A371V, I375V, A376T, S379C, K390R, E399D  
>3185-30429| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV
FAIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDIGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEIII
YQYVDDLYVASDLEIEQHRTKIKELRDYLLKWGFFTPEQKHQKEPPFLWMGYELHPEKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKSLTEVVTLTREAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLSQWTYQIYQEPFKNLKTGKYAKMRST
HTNDVKQLTEVVQKVTTECIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M Q58E, G73T L10I, K20R, E35D, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72L, V77I, I85V, I93L  
>3185-30429| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKIIGGIGGFVRVKEYE
QVPIEICGHKVLTTVLIGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006