Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3185 | 3185-30429 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, T215F | K219Q | K101P, G190A | V35I, K43Q, E44D, K64R, V111I, V118I, D123E, S162D, D177E, V179I, G196E, E203K, Q207D, H208Y, R211K, D218E, D237DE, A272S, T286A, A288S, I293V, P294T, E297KR, I326IV, Q334L, G335GS, R356K, G359S, A360AT, A371V, I375V, A376T, S379C, K390R, E399D |
| >3185-30429| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDIGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEIII YQYVDDLYVASDLEIEQHRTKIKELRDYLLKWGFFTPEQKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKSLTEVVTLTREAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLSQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEVVQKVTTECIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | Q58E, G73T | L10I, K20R, E35D, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72L, V77I, I85V, I93L |
| >3185-30429| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKIIGGIGGFVRVKEYE QVPIEICGHKVLTTVLIGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |