Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3184 | 3184-30429 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, Q58E, G73ST | L10I, I13V, K20R, L24F, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, A71V, I72IT |
| >3184-30429| codons 1-99 PQITLWQRPIVTVKIGGQLREALFDTGADDTVFEDIDLPGRWKPKLIGGIGGFVRVKEYD QVPIEICGHKVTTTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, T215Y | E6EK, K122E, D123E, V179VI, T200L, A272P, K281R, I293V, E297K, Q334E, F346CY, M357T, T369A, K374R, I375V, A376T, S379C |
| >3184-30429| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRLKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPYKNLKTGKYARTRGA HTNDVKQLAEAVQRVTTECIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |