Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3181 | 3181-30612 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K219R | T39A, K43E, E44D, V118I, K122E, I135T, S162H, V179I, T200A, E203V, Q207E, H208Y, R211K, K223Q, L228H, V292I, I293V, K311R, D324E, G359S, T369V, A371T |
| >3181-30612| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRKQNPDIII YQYIDDLYVGSDLEIGQHRAKIVELREYLWKWGFYTPDRKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILREPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLVETVQKIATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, V82T, L90M | V11VI, K43T, M46V, L89V | L10V, T12TS, I13V, K14KR, L19LP, K20IM, E21K, M36I, K55R, L63P, A71V |
| >3181-30612| codons 1-99 PQITLWQRPVISVRIGGQPMKALLDTGADDTILEEINLPGRWTPKVVGGIGGFMRVRQYD QIPIEICGHKVIGTVLVGPTPTNIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |