<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3176 3176-30425 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I47V, G48V, I54M, L76V, V82C, L90M F53L, G73A, L89V L10I, V11L, I13V, G16A, K20V, E34Q, N37D, L63P, H69Y, A71V, V77I, I93L  
>3176-30425| codons 1-99
PQITLWQRPILTVKIAGQLVEALLDTGADDTVLQEMDLPGRWKPKMVVGIGGLMKVRQYD
QIPIEICGYKVIATVVIGPTPCNIIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, V75T, M184V, L210W, T215Y K219N Y181C, G190S   T27S, K43E, E44A, K49R, E79D, R83K, K101Q, V111I, V118I, K122E, I142V, M164L, V179I, T200A, R211K, D218DE, K275R, Q278H, T286A, D324E, G359S, K390R R206I, P217S
>3176-30425| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEEAGKISRIGPENPYNTPV
FAIKKKNSTKWRKVTDFRDLNKKTQDFWEVQLGIPHPAGLQKKKSVTVLDIGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSLTKILEPFRKQNPDIII
CQYVDDLYVSSDLEIGQHRAKIEELIQHLWKWGFYTSENKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKHLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006