Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3176 | 3176-30425 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47V, G48V, I54M, L76V, V82C, L90M | F53L, G73A, L89V | L10I, V11L, I13V, G16A, K20V, E34Q, N37D, L63P, H69Y, A71V, V77I, I93L |
| >3176-30425| codons 1-99 PQITLWQRPILTVKIAGQLVEALLDTGADDTVLQEMDLPGRWKPKMVVGIGGLMKVRQYD QIPIEICGYKVIATVVIGPTPCNIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75T, M184V, L210W, T215Y | K219N | Y181C, G190S | T27S, K43E, E44A, K49R, E79D, R83K, K101Q, V111I, V118I, K122E, I142V, M164L, V179I, T200A, R206I, R211K, D218DE, K275R, Q278H, T286A, D324E, G359S, K390R | P217S |
| >3176-30425| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEEAGKISRIGPENPYNTPV FAIKKKNSTKWRKVTDFRDLNKKTQDFWEVQLGIPHPAGLQKKKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSLTKILEPFRKQNPDIII CQYVDDLYVSSDLEIGQHRAKIEELIQHLWKWGFYTSENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKHLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |