Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3175 | 3175-30422 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82F, L90M | V11I, L23I, L33F, F53L | L10I, I13V, K43S, I62V, L63P, A71V, I72V, T74A, V77I, I93L |
| >3175-30422| codons 1-99 PQITLWQRPIITVKIGGQLKEAILDTGADDTVFEEMNLPGRWSPKLIGGIGGLVKVRQYD QVPIEICGHKVVGAVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, M184V, L210W, T215Y | D67G, K219R | K103N | V108I, F227L | K20KR, T39A, V118I, K122E, I135T, I142V, Q174H, D177DN, G196E, T200TA, E203K, Q207E, H208HY, R211K, K223E, L228F, A272P, L283I, A288T, E297KPQT, E312EA, Q334L, R356K, G359S, T369A, A371V, K390R |
| >3175-30422| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKGSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPNIVI YQYVDDLYVGSDLEIEQHRAKIKELREYLWKWGFYTPDRKHQEEPPLFWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKTLTEVIPLTTEAE LELAENREILKAPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLAEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |