<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3175 3175-30422 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82F, L90M V11I, L23I, L33F, F53L L10I, I13V, K43S, I62V, L63P, A71V, I72V, T74A, V77I, I93L  
>3175-30422| codons 1-99
PQITLWQRPIITVKIGGQLKEAILDTGADDTVFEEMNLPGRWSPKLIGGIGGLVKVRQYD
QVPIEICGHKVVGAVLIGPTPFNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74V, M184V, L210W, T215Y D67G, K219R K103N V108I, F227L K20KR, T39A, V118I, K122E, I135T, I142V, Q174H, D177DN, G196E, T200TA, E203K, Q207E, H208HY, R211K, K223E, L228F, A272P, L283I, A288T, E297KPQT, E312EA, Q334L, R356K, G359S, T369A, A371V, K390R  
>3175-30422| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKGSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPNIVI
YQYVDDLYVGSDLEIEQHRAKIKELREYLWKWGFYTPDRKHQEEPPLFWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKTLTEVIPLTTEAE
LELAENREILKAPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLAEVVQKIATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006