<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3173 3173-30411 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54V, V82VA, I84V V11VI, L24I, G73GS, N83ND L10I, T12PS, I13IV, I15IV, L19IMT, K20IMR, A22AV, E35DN, M36I, N37D, I62IV, L63P, A71AITV  
>3173-30411| codons 1-99
PQITLWQRPIISVKVGGQTREVLIDTGADDTVLENIDLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVISTVLVGPTPADVIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219Q Y181C, G190S A98G K20R, V35VI, K64H, T69N, K101KQ, K102N, K122E, I135T, S162A, G196E, T200TI, I202V, H221HY, L228H, I293V, E297K, I329V, T386I  
>3173-30411| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLQNKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
CQYVDDLYVSSDLEIEQHRIKVEELRQHLLRWGFFTPDQKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006