Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3173 | 3173-30411 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82VA, I84V | V11VI, L24I, G73GS, N83ND | L10I, T12PS, I13IV, I15IV, L19IMT, K20IMR, A22AV, E35DN, M36I, N37D, I62IV, L63P, A71AITV |
| >3173-30411| codons 1-99 PQITLWQRPIISVKVGGQTREVLIDTGADDTVLENIDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPADVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219Q | Y181C, G190S | A98G | K20R, V35VI, K64H, T69N, K101KQ, K102N, K122E, I135T, S162A, G196E, T200TI, I202V, H221HY, L228H, I293V, E297K, I329V, T386I |
| >3173-30411| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLQNKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYVDDLYVSSDLEIEQHRIKVEELRQHLLRWGFFTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |