Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3171 | 3171-30409 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L10F, L33F, N88D | I13V, I62V, L63P, I64L, K70KQ, A71I, I72IV, P79A | L89S |
| >3171-30409| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFLKVRQYD QVPLEICGHQIVGTVLVGATPVNVIGRDSMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69DN, K70R, Q151M, M184V, T215F | F116Y, K219Q | Y181C, Y188L | K20KR, T39A, V60I, K122E, I135T, T139R, S162C, V179I, G196E, F214L, D218E, L228H, A272S, A288S, M357K, A376T, T386I, K390R, A400S | L209M |
| >3171-30409| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSTNNERPGIRYQYNVLPMGWKGSPAIFQCSMTKILEPFRKQNPDIII CQYVDDLLVGSDLEIEQHRTKIEELRQHMLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRGA HTNDVKQLTEAVQKITTESIVIWGKIPKFRLPIQKETWES |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |