<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3171 3171-30409 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54L, I84V, L90M L10F, L33F, N88D I13V, I62V, L63P, I64L, K70KQ, A71I, I72IV, P79A L89S
>3171-30409| codons 1-99
PQITLWQRPFVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFLKVRQYD
QVPLEICGHQIVGTVLVGATPVNVIGRDSMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69DN, K70R, Q151M, M184V, T215F F116Y, K219Q Y181C, Y188L   K20KR, T39A, V60I, K122E, I135T, T139R, S162C, V179I, G196E, F214L, D218E, L228H, A272S, A288S, M357K, A376T, T386I, K390R, A400S L209M
>3171-30409| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL
DEDFRKYTAFTIPSTNNERPGIRYQYNVLPMGWKGSPAIFQCSMTKILEPFRKQNPDIII
CQYVDDLLVGSDLEIEQHRTKIEELRQHMLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRGA
HTNDVKQLTEAVQKITTESIVIWGKIPKFRLPIQKETWES

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006