Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3170 | 3170-30409 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | V108VI | S3C, E6K, E44D, V106VL, K122E, D123E, I135T, T200A, Q207E, V245Q, T286A, I293V, D324DE, M357S, A371V, K390R |
| >3170-30409| codons 1-399 PICPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSLTILDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRAKIEELREHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARSRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L76V, I84V, L90M | G73C | L10I, K14KR, I15V, G16A, K20I, E34Q, R41RK, K55R, R57K, L63P, A71V, I72K, V77I, I85V |
| >3170-30409| codons 1-99 PQITLWQRPIVTIRVAGQLIEALLDTGADDTVLQEMNLPGKWKPKIVGGIGGFMRVKQYD QIPIEICGHKVKCTVVIGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |