<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3168 3168-30528 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219R K101E, Y181C, G190A A98G, V108I K11R, V35M, K43Q, R83K, K102Q, V118I, K122E, R172RK, K173E, G196E, Q207E, H208Y, R211K, H221Y, A272P, T286A, I293V, E297R, D324E, G335D, M357S, A360AT, K390R, Q394S, E399ED  
>3168-30528| codons 1-399
PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALMEICTELEQEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLEQKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKEQNPDIVI
CQYMDDLYVASDLEIEQHRTKIEELREYLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARSRGT
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPISKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, I84V, L90M L33F L10I, E34Q, I62V, L63P, A71V, V77I, I93L  
>3168-30528| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVIGTVVIGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006