Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3168 | 3168-30528 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L33F | L10I, E34Q, I62V, L63P, A71V, V77I, I93L |
| >3168-30528| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVIGTVVIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219R | K101E, Y181C, G190A | A98G, V108I | K11R, V35M, K43Q, R83K, K102Q, V118I, K122E, R172RK, K173E, G196E, Q207E, H208Y, R211K, H221Y, A272P, T286A, I293V, E297R, D324E, G335D, M357S, A360AT, K390R, Q394S, E399ED |
| >3168-30528| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALMEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLEQKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKEQNPDIVI CQYMDDLYVASDLEIEQHRTKIEELREYLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARSRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPISKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |