Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3167 | 3167-30502 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, I84IV | L24I, L33F | L10I, I13V, K55R, R57K, L63P, K70Q, A71V, T74S, V77IT, L89LM, I93L |
| >3167-30502| codons 1-99 PQITLWQRPIVTVKIGGQLKEALIDTGADDTIFEEMNLPGRWKPKIVGGIGGFMRVKQYD QIPIEICGHQVIGSVLTGPTPANVIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, Q151QKLM, M184V, L210W, T215Y | K219KE | Y181YC | E6EK, V21I, K43N, E44D, T69TA, V111I, K122E, I142T, S162Y, G196E, T200IL, R211EK, V245M, A272P, K277R, L283I, R284RK, I293V, E297KR, G333E, R358K, G359S, A360T, Q367L, A371V, T377R | G18GS, Y232YH |
| >3167-30502| codons 1-400 PISPIKTVPVKLKPGMDSPKIKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSAKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSVPL DEDFRKYTAFTIPSINNETPGTRYQYNVLPMGWKGSPAIFQYSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRLKIEELRQHLWKWGFYTPDEKHQKEPPFLWMGHELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIKGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMKST HTNDVKLLTEVVQKIARESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |