Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3166 | 3166-30424 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SG, T215F | Y181C, G190S | P4PS, T7TP, V35E, T39A, K122P, I135T, I142T, P176Q, V179VI, T200A, I202V, R211RK, L228H, A272P, K275R, Q278H, T286TA, I293IV, E297K, Q334E, K366R, A376T, T386A, K390R |
| >3166-30424| codons 1-399 PISSIEPVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNQDIII CQYMDDLYVSSDLEIGQHRAKVEELRQHLLKWGFFTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLTEAVQKITTESIVIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V | L24I, Q58E | L10V, I15V, K20V, E35N, M36I, K55KR, R57K, D60E, I62V, L63P, I64V, I72V, V82I |
| >3166-30424| codons 1-99 PQITLWQRPVVTIKVGGQLVEALIDTGADDTVLENINLPGRWKPKIIGGIGGFVRVKEYE QVPVEICGHKAVGTVVVGPTPINIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |