Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3165 | 3165-30507 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A, L90M | L33F, K43T | L10I, I13V, K20R, E35D, M36I, K55R, R57RK, D60E, I62V, L63P, A71V, L89M, I93L |
| >3165-30507| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDINLPGRWTPKLIGGIGGFVRVKQYE QVPIEICGHKVIGTVVVGPTPANIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67G, K219N | Y181C, G190A | V108VI | T39A, E44D, S68G, K101Q, K103KR, V118I, K122E, I135T, T200A, E203K, H208Y, R211K, K223E, L228H, A272P, R284K, T286A, I293V, P294A, I329V, Q334E, P345Q, V365I |
| >3165-30507| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKRKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRAKIKELRQYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVVALTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGEGQWTYQIYQEQFKNLKTGKYARMRGA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |