Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3164 | 3164-30425 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, L33F, Q58E, G73S | L10I, L19I, E35D, M36I, I62V, L63P, A71V, I72IL |
| >3164-30425| codons 1-99 PQITLWQRPIVTIKIGGQIKEALIDTGADDTVFEDINLPGRWKPKMIGGIGGFVKVREYD QVPIEICGHKVLSTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | V75I, K219Q | Y181C, G190A | K101H | P4S, T7P, P9S, V35K, T39A, S48E, K49R, K64H, V106I, D123E, I178L, I202IV, R211K, D218E, I293V, P294T, E297K, V317A, I329V, Q334E, E399G |
| >3164-30425| codons 1-400 PISSIEPVSVKLKPGMDGPKVKQWPLTEEKIKALKEICAELEKEGKIERIGPENPYNTPV FAIHKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLHKKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI CQYVDDLYVASDLEIGQHRTKVEELRQHLLKWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVTLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWGA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |