<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3164 3164-30425 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A L24I, L33F, Q58E, G73S L10I, L19I, E35D, M36I, I62V, L63P, A71V, I72IL  
>3164-30425| codons 1-99
PQITLWQRPIVTIKIGGQIKEALIDTGADDTVFEDINLPGRWKPKMIGGIGGFVKVREYD
QVPIEICGHKVLSTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, T215Y V75I, K219Q Y181C, G190A K101H P4S, T7P, P9S, V35K, T39A, S48E, K49R, K64H, V106I, D123E, I178L, I202IV, R211K, D218E, I293V, P294T, E297K, V317A, I329V, Q334E, E399G  
>3164-30425| codons 1-400
PISSIEPVSVKLKPGMDGPKVKQWPLTEEKIKALKEICAELEKEGKIERIGPENPYNTPV
FAIHKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLHKKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
CQYVDDLYVASDLEIGQHRTKVEELRQHLLKWGFYTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVTLTKEAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWGA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006