<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3162 3162-30418 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47V, I54M, V82T, L90M L10F, K43T, L89V I15V, K20R, E35D, M36I, N37D, L63P, A71IV, I85V  
>3162-30418| codons 1-99
PQITLWQRPFVTIKVGGQLREALLDTGADDTILEDIDLPGRWTPKMVGGIGGFMKVRQYD
QIPIEICGHKVIGTVLVGPTPTNIVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69T_VT, L74V, M184V, L210W, T215Y A62V, D67E K103HN, Y181C, G190A K101HQ K20R, E28A, T39A, A98S, K122E, I135T, Q174R, I178L, G196E, E203D, R211K, L228R, R284K, T286A, E291D, E297K, I329L, G333E, Q334H, M357V, A376CST, T386I, K395R, E399ED  
>3162-30418| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTAEKIKALVEICAELEKEGKISKIGPENPYNTPV
FVIKKKESTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLQKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDLVI
CQYVDDLYVASDLEIEQHRTKIDELRQHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTDVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQEHGQWTYQIYQEPFKNLKTGKYARVRGA
HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPIQRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006