Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3161 | 3161-30416 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, L76V, I84V | L10I, T12P, G16GE, K20KT, I62IV, L63AV, A71V, L89LM, I93L |
| >3161-30416| codons 1-99 PQITLWQRPIVPIKIEGQLTEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFIKVRQYD QVVIEICGHKVIGTVVVGPTPVNVIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219KN | Y188L | Y318F | V35VI, K43KN, E44D, V60I, K101KQ, V118I, D121H, K122E, D123S, I135V, K173KR, D177E, V179IL, Q207E, R211K, A272P, K275R, K277R, T286A, A288T, I293V, E297A, Q334N, G335GD, A360T, A371V, I375V |
| >3161-30416| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL HESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRQNPEILI YQYMDDLLVGSDLEIGQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGAKTLTEVVPLTAEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEVVQKVATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |