<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3161 3161-30416 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, L76V, I84V   L10I, T12P, G16GE, K20KT, I62IV, L63AV, A71V, L89LM, I93L  
>3161-30416| codons 1-99
PQITLWQRPIVPIKIEGQLTEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFIKVRQYD
QVVIEICGHKVIGTVVVGPTPVNVIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219KN Y188L Y318F V35VI, K43KN, E44D, V60I, K101KQ, V118I, D121H, K122E, D123S, I135V, K173KR, D177E, V179IL, Q207E, R211K, A272P, K275R, K277R, T286A, A288T, I293V, E297A, Q334N, G335GD, A360T, A371V, I375V  
>3161-30416| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
HESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRQNPEILI
YQYMDDLLVGSDLEIGQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGAKTLTEVVPLTAEAE
LELAENREILKEPVHGVFYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLTEVVQKVATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006