Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3160 | 3160-30408 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W | T215C, K219E | K103N | V108I | P4PS, E6K, V35M, T39A, E40EG, E44D, V90VI, V118I, K122E, I135V, G196E, Q197H, E203K, Q207E, R211A, K223T, V245T, R284K, I293V, E297A, A327V, M357T, G359GS, I375V, A376S, T377M, S379C, K390R, K395R |
| >3160-30408| codons 1-399 PISSIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAGLEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEHHRTKIKELREHLWAWGFCTPDEKHQTEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIVEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEAVQKVSMECIVIWGKTPKFRLPIQRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, K43T | L10I, E34Q, E35D_RF, N37ND, G51A, K55R, Q61E, I62V, L63P, A71T, I72V, V77I, I93L | T80TI |
| >3160-30408| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQDMDLPGRWTPKIIGGIAGFVRVRQYD EVPIEICGHKTVGTVLIGPIPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |