<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3160 3160-30408 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, K43T L10I, E34Q, E35D_RF, N37ND, G51A, K55R, Q61E, I62V, L63P, A71T, I72V, V77I, I93L T80TI
>3160-30408| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQDMDLPGRWTPKIIGGIAGFVRVRQYD
EVPIEICGHKTVGTVLIGPIPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W T215C, K219E K103N V108I P4PS, E6K, V35M, T39A, E40EG, E44D, V90VI, V118I, K122E, I135V, G196E, Q197H, E203K, Q207E, R211A, K223T, V245T, R284K, I293V, E297A, A327V, M357T, G359GS, I375V, A376S, T377M, S379C, K390R, K395R  
>3160-30408| codons 1-399
PISSIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAGLEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEHHRTKIKELREHLWAWGFCTPDEKHQTEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIVEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEAVQKVSMECIVIWGKTPKFRLPIQRETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006