<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3159 3159-30402 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184I, L210W, T215Y K219R K103N A98G, V108I, F227L V35IM, T39A, K43Q, E44D, V118I, D123E, T139R, I142T, S162C, I178M, V179I, T200TA, E203K, H208Y, R211K, K223E, L228H, A272P, V292VI, I293V, Q334N, G335S, R356K, G359S, A360T, A376S, S379C, T386I, K390KR  
>3159-30402| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEQDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL
DKEFRKYTAFTIPSINNERPGTRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMII
YQYIDDLYVGSDLEIGQHRAKIKELRQYLWKWGFYTPDRKHQEEPPLHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYAKMRST
HTNDVKQLTEAVQKISTECIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I50V, I54V, V82A L10F, F53L K14R, I15V, L19P, K20I, E35N, M36I, N37D, R41T, K45V, I62V, I64V, A71V, I85V, L89I  
>3159-30402| codons 1-99
PQITLWQRPFVTIRVGGQPIEALLDTGADDTVLENIDLPGTWKPVMIGGVGGLVKVRQYD
QVLVEICGHKVIGTVLVGPTPANIVGRNILTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006