Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3159 | 3159-30402 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V, I54V, V82A | L10F, F53L | K14R, I15V, L19P, K20I, E35N, M36I, N37D, R41T, K45V, I62V, I64V, A71V, I85V, L89I |
| >3159-30402| codons 1-99 PQITLWQRPFVTIRVGGQPIEALLDTGADDTVLENIDLPGTWKPVMIGGVGGLVKVRQYD QVLVEICGHKVIGTVLVGPTPANIVGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K219R | K103N | A98G, V108I, F227L | V35IM, T39A, K43Q, E44D, V118I, D123E, T139R, I142T, S162C, I178M, V179I, T200TA, E203K, H208Y, R211K, K223E, L228H, A272P, V292VI, I293V, Q334N, G335S, R356K, G359S, A360T, A376S, S379C, T386I, K390KR |
| >3159-30402| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINNERPGTRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMII YQYIDDLYVGSDLEIGQHRAKIKELRQYLWKWGFYTPDRKHQEEPPLHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEAVQKISTECIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |