Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3153 | 3153-30416 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | Y181V | V108VI | T39E, E44D, V60I, V118I, K122E, I135L, V179I, R211RQ, H221Y, V245T, K277R, Q278E, T286A, I293V, E297K, V317VA, I329V, Q334L, G335GS, G359S, A371V, A376S, T386I, Q394L |
| >3153-30416| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII VQYMDDLYVGSDLEIGQHRTKIEELRQHLWQWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISTESIVIWGKIPKFKLPILKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, I84V, L90M | L10FI, G73T | L19IV, I62V, L63P, I66IV, A71V, V77I, P79A, I93L |
| >3153-30416| codons 1-99 PQITLWQRPIVTIKIGGQVKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVPIEVCGHKVITTVLIGATPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |