<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3153 3153-30416 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54V, I84V, L90M L10FI, G73T L19IV, I62V, L63P, I66IV, A71V, V77I, P79A, I93L  
>3153-30416| codons 1-99
PQITLWQRPIVTIKIGGQVKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QVPIEVCGHKVITTVLIGATPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219R Y181V V108VI T39E, E44D, V60I, V118I, K122E, I135L, V179I, R211RQ, H221Y, V245T, K277R, Q278E, T286A, I293V, E297K, V317VA, I329V, Q334L, G335GS, G359S, A371V, A376S, T386I, Q394L  
>3153-30416| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPI
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
VQYMDDLYVGSDLEIGQHRTKIEELRQHLWQWGFYTPDRKYQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLSQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKISTESIVIWGKIPKFKLPILKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006