<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3151 3151-30416 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S L24I L10V, K14KR, I15V, K20T, E34Q, M36MI, R41K, I62V, L63P, A71AV, T74S, V77I  
>3151-30416| codons 1-99
PQITLWQRPVVTIRVGGQLTEALIDTGADDTVLQEINLPGKWKPKMIVGIGGFVKVRQYD
QVPIEICGHKVIGSVLIGPTPSNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M, K219N     K20R, T27TS, V35I, K43Q, E44D, K49Q, K122E, I135T, S162Y, G196E, Q207E, R211K, V245E, P294Q, K350R, R356K, G359S, A371V, A376T, T386A, K390KR, Q394QH, K395R, E399D  
>3151-30416| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALIEICTELEQDGKISQIGPENPYNTPV
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYAKMRSA
HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIHRETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006