Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3151 | 3151-30416 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S | L24I | L10V, K14KR, I15V, K20T, E34Q, M36MI, R41K, I62V, L63P, A71AV, T74S, V77I |
| >3151-30416| codons 1-99 PQITLWQRPVVTIRVGGQLTEALIDTGADDTVLQEINLPGKWKPKMIVGIGGFVKVRQYD QVPIEICGHKVIGSVLIGPTPSNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219N | K20R, T27TS, V35I, K43Q, E44D, K49Q, K122E, I135T, S162Y, G196E, Q207E, R211K, V245E, P294Q, K350R, R356K, G359S, A371V, A376T, T386A, K390KR, Q394QH, K395R, E399D |
| >3151-30416| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALIEICTELEQDGKISQIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYAKMRSA HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIHRETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |