<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3150 3150-30416 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y K219N Y188L   T39TA, K43KQ, E44D, K49R, K102W, V118I, K122E, S162C, E169D, Q174QR, D177E, I178L, G196E, T200A, E203V, Q207D, H208Y, R211K, D218E, I293V, E297K, G333E, K350R, G359S, A371V, K388T, K390R  
>3150-30416| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISRIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKRNPELVI
YQYVDDLLVGSDLEIEQHRAKIVELRDYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPTFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M V11I, G73T L10I, I13V, I15V, L19T, K20I, M36I, D60E, Q61E, I62V, L63P, C67CY, A71T, I72T, T91S  
>3150-30416| codons 1-99
PQITLWQRPIITVKVGGQTIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYE
EVPIEIYGHKTTTTVLVGPTPVNVIGRNLMSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006