Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3150 | 3150-30416 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | Y188L | T39TA, K43KQ, E44D, K49R, K102W, V118I, K122E, S162C, E169D, Q174QR, D177E, I178L, G196E, T200A, E203V, Q207D, H208Y, R211K, D218E, I293V, E297K, G333E, K350R, G359S, A371V, K388T, K390R |
| >3150-30416| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISRIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKRNPELVI YQYVDDLLVGSDLEIEQHRAKIVELRDYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPTFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11I, G73T | L10I, I13V, I15V, L19T, K20I, M36I, D60E, Q61E, I62V, L63P, C67CY, A71T, I72T, T91S |
| >3150-30416| codons 1-99 PQITLWQRPIITVKVGGQTIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYE EVPIEIYGHKTTTTVLVGPTPVNVIGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |