Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3149 | 3149-30429 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54IV, V82VA, L90LM | K43T, N88ND | L10LV, I15V, K20KMR, E35D, M36MI, N37HQ, I62IV, L63P, A71AV, I72T |
| >3149-30429| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDIQLPGRWTPKLIGGIGGFVKVRQYD QVPIEICGHKVTGTVLVGPTPANIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, T69AD, M184MV, L210LW, T215TNSY | K219KR | V35IL, T39TA, E44ED, V118VI, F171FY, T200I, E203ED, Q207D, E248D, L283I, I293V, V317VA, I329IV, G359S, A371V, K390R |
| >3149-30429| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIDELRDHLWRWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |