Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3148 | 3148-30408 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54IV, V82A, L90M | L10F, L33F | I13V, K14M, E35D, N37D, L63P, A71V, I72IV, P79Q, I93L |
| >3148-30408| codons 1-99 PQITLWQRPFVTVMIGGQLKEALLDTGADDTIFEDMDLPGRWKPKIVGGIGGFVKVRQYD QIPIEICGHKVVGTVLVGQTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100I, K103N | K43KN, E44ED, V60I, K122E, E203K, Q207E, R211K, D250E, A272P, I293IV, D324E, I329L, Q334P, M357MT, A360T, I375IV |
| >3148-30408| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGPGQWTYQIYQEPFKNLKTGKYARTRGT HTNDVKQLTEAVQKVATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |