Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3146 | 3146-30514 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219R | Y181C, G190A | K101H, V108I, F227L | E6D, K20R, E28EK, K43Q, E44D, V60I, V118I, K122E, D123E, I135T, K166R, D177E, T200E, E203K, Q207E, H208Y, H221Y, K223E, A272P, K277R, E291D, E297K, M357T, V365I, T369V, A376T, S379G, T386A, K390R, K395R, E399D |
| >3146-30514| codons 1-399 PISPIDTVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYVDDLYVASDLEIGQHREKIKELREYLWRWGFYTPDRKYQEEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDIKQLVEAVQKITTEGIVIWGKAPKFRLPIQRETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | V11I, F53L, G73S | T4TS, L10V, I15V, L19I, M36L, N37D, L38W, R41K, K55R, R57RK, I62V, L63P, A71V, I72IL |
| >3146-30514| codons 1-99 PQISLWQRPVITIKVGGQIKEALLDTGADDTVLEELDWPGKWKPKLIGGIGGLVRVKQYD QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |