<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3146 3146-30514 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y K219R Y181C, G190A K101H, V108I, F227L E6D, K20R, E28EK, K43Q, E44D, V60I, V118I, K122E, D123E, I135T, K166R, D177E, T200E, E203K, Q207E, H208Y, H221Y, K223E, A272P, K277R, E291D, E297K, M357T, V365I, T369V, A376T, S379G, T386A, K390R, K395R, E399D  
>3146-30514| codons 1-399
PISPIDTVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTILDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI
CQYVDDLYVASDLEIGQHREKIKELREYLWRWGFYTPDRKYQEEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDIKQLVEAVQKITTEGIVIWGKAPKFRLPIQRETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M V11I, F53L, G73S T4TS, L10V, I15V, L19I, M36L, N37D, L38W, R41K, K55R, R57RK, I62V, L63P, A71V, I72IL  
>3146-30514| codons 1-99
PQISLWQRPVITIKVGGQIKEALLDTGADDTVLEELDWPGKWKPKLIGGIGGLVRVKQYD
QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006