Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3145 | 3145-30429 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K101P, K103S | T27S, V35T, K43N, V60I, V90I, V118I, K122E, D123N, I135T, E138Q, N175Y, T200K, K201I, R211K, A272AP, T286A, E297A, D324E, I329L, A360AT |
| >3145-30429| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTEICTELENEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLPKSKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQYPDIVI YQYVDDLYVGSDLEIGQHRKIIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L24I, L33F, K43T | L10I, I13V, E35D, M36L, N37T, R57K, I62V, L63P, I64V |
| >3145-30429| codons 1-99 PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFEDLTLPGRWTPKIIGGIGGFVKVKQYD QVPVEICGHKAIGTVVVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |