<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3145 3145-30429 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A L24I, L33F, K43T L10I, I13V, E35D, M36L, N37T, R57K, I62V, L63P, I64V  
>3145-30429| codons 1-99
PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFEDLTLPGRWTPKIIGGIGGFVKVKQYD
QVPVEICGHKAIGTVVVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y   K101P, K103S   T27S, V35T, K43N, V60I, V90I, V118I, K122E, D123N, I135T, E138Q, N175Y, T200K, K201I, R211K, A272AP, T286A, E297A, D324E, I329L, A360AT  
>3145-30429| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTEICTELENEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLPKSKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQYPDIVI
YQYVDDLYVGSDLEIGQHRKIIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006